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Abstract #0844

Automatic combined whole-body muscle and fat volume quantification using water-fat separated MRI in postmenopausal women

Janne West 1,2 , Thobias Romu 2,3 , Anna-Clara Spetz Holm 4 , Hanna Lindblom 1 , Lotta Lindh-strand 4 , Magnus Borga 2,3 , Mats Hammar 4 , and Olof Dahlqvist Leinhard 1,2

1 Department of Medical and Health Sciences, Linkping University, Linkping, Sweden, 2 Center for Medical Imaging Science and Visualization, Linkping, Sweden, 3 Department of Biomedical Engineering, Linkping University, Linkping, Sweden, 4 Department of Clinical and Experimental Medicine, Linkping University, Linkping, Sweden

Quantitative and exact measurements of fat and muscle in the body are important when addressing some of the greatest health-challenges today. In this study whole-body combined regional muscle and fat volume quantification was validated in a group of postmenopausal women, where the body composition is changing. Twelve subjects were scanned with a 4-echo 3D gradient-echo sequence. Water and fat image volumes were calculated using IDEAL, and image intensity correction was performed. Subsequently, automatic tissue segmentation was established using non-rigid morphon based registration. Whole-body regional fat and muscle segmentation could be performed with excellent test-retest reliability, in a single 7-minutes MR-scan.

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