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Abstract #0848

Imaging of Dissolved-phase Hyperpolarized Xenon-129 in Human Kidneys

John P. Mugler, III 1 , G. Wilson Miller 1 , Craig H. Meyer 2 , Kun Qing 1 , Jaime F. Mata 1 , Steven Guan 2 , Kai Ruppert 1,3 , Iulian C. Ruset 4,5 , F. William Hersman 4,5 , and Talissa A. Altes 1

1 Radiology & Medical Imaging, University of Virginia, Charlottesville, VA, United States, 2 Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, 3 Cincinnati Children's Hospital, Cincinnati, OH, United States, 4 Xemed, LLC, Durham, NH, United States, 5 Physics, University of New Hampshire, Durham, NH, United States

The purpose of this work was to determine if 129Xe can be detected in human abdominal organs, such as the kidneys. Dissolved-phase 129Xe imaging was performed at 1.5T in two healthy subjects. Dissolved-phase 129Xe was seen in the kidneys of both subjects, and a linear structure, consistent with the position of the descending aorta, was seen passing between the kidneys and bifurcating below the kidneys. These results may be of interest for kidney perfusion imaging. In addition, if multiple 129Xe resonances can be detected in the kidneys, dissolved-phase 129Xe imaging may offer additional interesting information on kidney function and disease.

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