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Abstract #0849

Renal Blood Oxygenation Level-Dependent Imaging in Longitudinal Follow-up of the Donated and the Remaining Kidney in Renal Transplantation

Maryam Seif 1 , Ute Eisenberger 2 , Tobias Binser 1 , Harriet C Thoeny 3 , Fabienne Krauer 1 , Chris Boesch 1 , Bruno Vogt 4 , and Peter Vermathen 1

1 Depts. Radiology and Clinical Research, University Bern, Bern, Switzerland, 2 Dept. Nephrology, University Hospital Essen-Duisburg, Essen, Germany, 3 Dept. Radiology, Neuroradiology and Nuclear Medicine, University Hospital of Bern, Bern, Switzerland, 4 Dept. Nephrology, Hypertension and Clinical Pharmacology, University Hospital of Bern, Bern, Switzerland

We determined renal oxygenation changes associated with uninephrectomy and transplantation in both, remaining and transplanted kidneys using blood oxygenation level-dependent (BOLD) MRI. Thirteen healthy kidney donors and their corresponding recipients underwent kidney BOLD MRI. BOLD MRI was performed in donors before uninephrectomy and in donors and recipients at day 8, month 3 and 12 after transplantation. BOLD MRI detects increased oxygen content in the remaining kidney of living kidney donors as very early adaptation to transplantation of the contralateral kidney. In contrast, the oxygen content in the transplanted kidney remains very constant.

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