Abstract #0849
Renal Blood Oxygenation Level-Dependent Imaging in Longitudinal Follow-up of the Donated and the Remaining Kidney in Renal Transplantation
Maryam Seif 1 , Ute Eisenberger 2 , Tobias Binser 1 , Harriet C Thoeny 3 , Fabienne Krauer 1 , Chris Boesch 1 , Bruno Vogt 4 , and Peter Vermathen 1
1
Depts. Radiology and Clinical Research,
University Bern, Bern, Switzerland,
2
Dept.
Nephrology, University Hospital Essen-Duisburg, Essen,
Germany,
3
Dept. Radiology, Neuroradiology and
Nuclear Medicine, University Hospital of Bern, Bern,
Switzerland,
4
Dept.
Nephrology, Hypertension and Clinical Pharmacology,
University Hospital of Bern, Bern, Switzerland
We determined renal oxygenation changes associated with
uninephrectomy and transplantation in both, remaining
and transplanted kidneys using blood oxygenation
level-dependent (BOLD) MRI. Thirteen healthy kidney
donors and their corresponding recipients underwent
kidney BOLD MRI. BOLD MRI was performed in donors before
uninephrectomy and in donors and recipients at day 8,
month 3 and 12 after transplantation. BOLD MRI detects
increased oxygen content in the remaining kidney of
living kidney donors as very early adaptation to
transplantation of the contralateral kidney. In
contrast, the oxygen content in the transplanted kidney
remains very constant.
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