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Abstract #0850

Redistribution of Fractional Ventilation after Circumscribed Primary Lung Injury and Atelectasis

Yi Xin 1 , Maurizio Cereda 2 , Hooman Hamedani 1 , Harrilla Profka 1 , Justin Clapp 1 , Stephen Kadlecek 1 , Brian P. Kavanagh 3 , and Rahim R. Rizi 1

1 Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2 Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, United States, 3 Hospital for Sick Children, Toronto, Ontario, Canada

Atelectasis and mild local lung injury cause redistribution of inspired gas to residual ventilated airspaces, resulting in their over-ventilation and potentially damaging ventilatory stress. This dynamic can be spatially evaluated by hyperpolarized 3He imaging. Hyperpolarized 3He maps of fractional ventilation (r) demonstrate that recruitment with PEEP attenuates residual over-ventilation in HCl models of circumscribed lung injury.

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