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Abstract #0882

Evidence of Early Left Ventricular Dysfunction in Bicuspid Aortic Valve Patients Identified by MRI-Based Wave Intensity Analysis

Nicholas Scott Burris 1 , Petter Dyverfeldt 2 , and Michael D Hope 1

1 Radiology, University of California San Francisco, San Francisco, CA, United States, 2 Center for Medical Image Science and Visualization, Linkping University, Linkping, Sweden

Bicuspid aortic valve (BAV) is a common congenital cardiac abnormality associated with abnormal aortic flow, increased aortic stiffness and valvular dysfunction, which may predispose to abnormal ventricular-arterial coupling. Wave intensity analysis (WIA) was used to measure a maker left ventricular function, forward compression wave (FCW), using 2D phase-contrast MRI. We found decreased average FCW values in BAV patients compared to normal patients. Amongst BAV patients, two features of BAV-aortopathy (aortic stiffness and aortic diameter) were found to predict decreases in FCW. WIA may identify early and adverse changes in ventricular-arterial coupling in patients with BAV that would otherwise go unnoticed.

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