Robust Quantification of Background Parenchymal Enhancement (BPE) in Dynamic Contrast-Enhanced (DCE) MRI Breast Examinations
Araminta EW Ledger 1 , Maria A Schmidt 1 , Marco Borri 1 , Steven Allen 2 , Elizabeth AM O'Flynn 2 , Romney J Pope 2 , Erica D Scurr 2 , Nandita deSouza 1 , Robin Wilson 2 , and Martin O Leach 1
CR-UK Cancer Imaging Centre, The Institute
of Cancer Research and Royal Marsden NHS Foundation
Trust, Sutton, Surrey, United Kingdom,
The Royal Marsden NHS Foundation Trust, Sutton, Surrey,
Background Parenchymal Enhancement (BPE) following
contrast agent (CA) administration in DCE-MRI breast
examinations may be related to breast cancer risk.
However, BPE is typically evaluated via visual
assessment of subtracted images where signal intensity
changes are dependent on native T1 relaxation times.
Instead, the difference in relaxivity (ΔR1) provides a
measure directly proportional to CA uptake. We evaluated
objective BPE measures, including ΔR1 and a normalized
parenchymal enhancement coefficient (PEC), and compared
these measures against relative enhancement (RE).
Evaluation of ΔR1 provides an objective and translatable
BPE measure which should be utilized for risk assessment
in longitudinal and multicenter studies.
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