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Abstract #0888

Robust Quantification of Background Parenchymal Enhancement (BPE) in Dynamic Contrast-Enhanced (DCE) MRI Breast Examinations

Araminta EW Ledger 1 , Maria A Schmidt 1 , Marco Borri 1 , Steven Allen 2 , Elizabeth AM O'Flynn 2 , Romney J Pope 2 , Erica D Scurr 2 , Nandita deSouza 1 , Robin Wilson 2 , and Martin O Leach 1

1 CR-UK Cancer Imaging Centre, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom, 2 Radiology, The Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

Background Parenchymal Enhancement (BPE) following contrast agent (CA) administration in DCE-MRI breast examinations may be related to breast cancer risk. However, BPE is typically evaluated via visual assessment of subtracted images where signal intensity changes are dependent on native T1 relaxation times. Instead, the difference in relaxivity (ΔR1) provides a measure directly proportional to CA uptake. We evaluated objective BPE measures, including ΔR1 and a normalized parenchymal enhancement coefficient (PEC), and compared these measures against relative enhancement (RE). Evaluation of ΔR1 provides an objective and translatable BPE measure which should be utilized for risk assessment in longitudinal and multicenter studies.

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