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Abstract #0890

7T Breast MRI to Visualize Proliferative Characteristics of Breast Cancer using DCE, DWI, and 31 P-MRS

Alexander M. Th. Schmitz 1 , Wouter B. Veldhuis 1 , Marian B.E. Menke-Pluijmers 2 , Wybe J.M. van der Kemp 1 , Tijl A. van der Velden 1 , Marc C.J.M. Kock 3 , Pieter J. Westenend 4 , Dennis W.J. Klomp 1 , and Kenneth G.A. Gilhuijs 1

1 Department of Radiology/Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands, 2 Department of Surgery, Albert Schweitzer Hospital, Dordrecht, Netherlands, 3 Department of Radiology, Albert Schweitzer Hospital, Dordrecht, Netherlands, 4 Department of Pathology, Albert Schweitzer Hospital, Dordrecht, Netherlands

Breast cancer therapy would benefit from more accurate tumor characterization early in therapy, especially concerning tumor proliferation. MRI may provide additional information early in treatment. In-vivo characterization using DWI and MRS may be beneficial, but the ability of 1.5 and 3T MRI systems to provide clinically useful information is limited by their sensitivity. In this study, a 7T breast MRI multi-protocol was developed including DCE-MRI, DWI and 31 P-MRS. Fifteen women were included with 17 malignant lesions. First explorations in correlation with histopathology show potential of DWI and 31 P-MRS to visualize biomarkers of tumor proliferation.

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