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Abstract #0901

Cerebral blood flow is mediated by brain cells expressing glucose transporter 2

Hongxia Lei 1,2 , Frederic Preitner 3 , Bernard Thorens 3 , and Rolf Gruetter 4,5

1 AIT, Center for Biomedical Imaging (CIBM), Ecole Polytechnique Fdrale de Lausanne, Lausanne, Vaud, Switzerland, 2 University of Geneva, Geneva, Geneva, Switzerland, 3 Center for Integrative Genomics (CIG), University of Lausanne, Lausanne, Vaud, Switzerland, 4 Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Vaud, Switzerland, 5 Department of Radiology, University of Lausanne, Lausanne, Vaud, Switzerland

Glucose transporter isoform 2 (glut2) has been shown to not only meditating glucose sensing mechanism in pancreatic tissue but also preferentially being highly located in brain regions and nuclei which regulate the neuroendocrine and autonomic nervous system. we hypothesized that glut2 positive brain cells might be involved in glucose sensing mechanism in brain and thus deleting glut2 would affect brain metabolism under euglycemia and mediate vascular responses upon hypoglycemia. This study applied a non-invasive perfusion MRI technique, continuous arterial spin labeling (CASL), to measure cerebral blood flow (CBF) under euglycemia and upon hypoglycemia in glut2 positive brain cells nulled mice compared to their countertypes. Unlike the elevated CBF increases in the wild type mice, the dimished repsponses were observed. We conclude that brain cells expressing glut2 are implicated in regulating the CBF response to hypoglycemia.

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