Abstract #0901
Cerebral blood flow is mediated by brain cells expressing glucose transporter 2
Hongxia Lei 1,2 , Frederic Preitner 3 , Bernard Thorens 3 , and Rolf Gruetter 4,5
1
AIT, Center for Biomedical Imaging (CIBM),
Ecole Polytechnique Fdrale de Lausanne, Lausanne,
Vaud, Switzerland,
2
University
of Geneva, Geneva, Geneva, Switzerland,
3
Center
for Integrative Genomics (CIG), University of Lausanne,
Lausanne, Vaud, Switzerland,
4
Laboratory
for Functional and Metabolic Imaging, Ecole
Polytechnique Fdrale de Lausanne, Lausanne, Vaud,
Switzerland,
5
Department
of Radiology, University of Lausanne, Lausanne, Vaud,
Switzerland
Glucose transporter isoform 2 (glut2) has been shown to
not only meditating glucose sensing mechanism in
pancreatic tissue but also preferentially being highly
located in brain regions and nuclei which regulate the
neuroendocrine and autonomic nervous system. we
hypothesized that glut2 positive brain cells might be
involved in glucose sensing mechanism in brain and thus
deleting glut2 would affect brain metabolism under
euglycemia and mediate vascular responses upon
hypoglycemia. This study applied a non-invasive
perfusion MRI technique, continuous arterial spin
labeling (CASL), to measure cerebral blood flow (CBF)
under euglycemia and upon hypoglycemia in glut2 positive
brain cells nulled mice compared to their countertypes.
Unlike the elevated CBF increases in the wild type mice,
the dimished repsponses were observed. We conclude that
brain cells expressing glut2 are implicated in
regulating the CBF response to hypoglycemia.
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