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Abstract #0900

Temporal and spatial changes of BOLD signal, CBF and CBV in the activated human visual cortex during mild hypoxia

Felipe Rodrigues Barreto 1 , Silvia Mangia 2 , and Carlos Ernesto Garrido Salmon 3

1 Department of Physics, University of Sao Paulo, RIbeirao Preto, SP, Brazil, 2 Department of Radiology, CMRR, University of Minnesota, MN, United States, 3 Department of Physics, University of Sao Paulo, Ribeirao Preto, SP, Brazil

In the present study we used multimodal fMRI to quantify in the human visual cortex the effects of mild hypoxic hypoxia on stimulus induced variations of cerebral blood flow (CBF), cerebral blood volume (CBV), BOLD signal, as well as oxygen consumption (CMRO2) and oxygen extraction fraction (OEF) during visual stimulation. Hypoxia produced substantial reductions in the active volumes detected in BOLD, CBF and CBV images, which might indicate smaller cortex recruitment. The brain regions commonly activated during hypoxia and normoxia had reduced BOLD amplitudes and smaller OEF reductions, but no changes in the amplitude of vascular and CMRO2 responses.

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