Abstract #0900
Temporal and spatial changes of BOLD signal, CBF and CBV in the activated human visual cortex during mild hypoxia
Felipe Rodrigues Barreto 1 , Silvia Mangia 2 , and Carlos Ernesto Garrido Salmon 3
1
Department of Physics, University of Sao
Paulo, RIbeirao Preto, SP, Brazil,
2
Department
of Radiology, CMRR, University of Minnesota, MN, United
States,
3
Department of Physics, University of
Sao Paulo, Ribeirao Preto, SP, Brazil
In the present study we used multimodal fMRI to quantify
in the human visual cortex the effects of mild hypoxic
hypoxia on stimulus induced variations of cerebral blood
flow (CBF), cerebral blood volume (CBV), BOLD signal, as
well as oxygen consumption (CMRO2) and oxygen extraction
fraction (OEF) during visual stimulation. Hypoxia
produced substantial reductions in the active volumes
detected in BOLD, CBF and CBV images, which might
indicate smaller cortex recruitment. The brain regions
commonly activated during hypoxia and normoxia had
reduced BOLD amplitudes and smaller OEF reductions, but
no changes in the amplitude of vascular and CMRO2
responses.
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