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Abstract #0899

Blood oxygenation, CBF, OEF, and CMRO2 changes during hypercapnia and hyperoxia using pCASL and TRUST MRI

Jeroen C.W. Siero 1 , Carlos C. Faraco 2 , Alex Bhogal 1 , Megan K. Strother 2 , Peiying Liu 3 , Hanzhang Lu 3 , Jeroen Hendrikse 1 , and Manus J. Donahue 2

1 Radiology, University Medical Center Utrecht, Utrecht, Utrecht, Netherlands, 2 Radiology and Radiological Sciences, Nashville, Vanderbilt University School of Medicine, Tennessee, United States, 3 Radiology Advanced Imaging Research Center, UTSouthwestern Medical Center, Texas, United States

Here we evaluate the assumption that two common hypercapnic stimuli (5%CO2; and carbogen) are iso-metabolic using MRI-based measures of changes in venous blood oxygenation. Wholebrain CBF (pCASL), and Yv (TRUST-MRI) changes were measured for hypercapnic-normoxia, normocapnia-hyperoxia, and hypercapnic-hyperoxia stimuli allowing calculation of OEF and CMRO2. After correcting for the plasma-dissolved arterial and venous O2, no significant differences in OEF were found between 5%CO2 and carbogen. Significant CMRO2 decreases from room air were observed only for the hypercapnic-normoxic condition. We believe these findings will be of importance for interpreting calibrated fMRI and BOLD CVR measurements using hypercapnic or carbogen stimuli.

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