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Abstract #0898

Three-dimensional acquisition of cerebral blood volume, blood flow and blood oxygenation-weighted responses during functional stimulation in a single scan

Ying Cheng 1,2 , Qin Qin 1,3 , Peter C. M. van Zijl 1,3 , James J. Pekar 1,3 , and Jun Hua 1,3

1 F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, United States, 2 Dept. of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States, 3 Neurosection, Div. of MRI Research, Dept. of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland, United States

Quantitative approaches have been developed to estimate CMRO2 dynamics from BOLD, CBF, and CBV responses. The ability to measure BOLD, CBF, and CBV signals in one single scan would be useful to improve acquisition efficiency and reduce temporal variations. We extended the recently proposed 3D VASO-FAIR approach, which combines the VASO and FAIR-ASL techniques to simultaneously detect CBV and CBF responses, with a T2-preparation module to induce T2-weighted BOLD contrast, allowing concurrent measurement of BOLD, CBV, and CBF responses. For visual stimulation, the proposed method could achieve similar activation patterns, image quality, tSNR, and CNR as the separate individual scans.

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