Abstract #0898
Three-dimensional acquisition of cerebral blood volume, blood flow and blood oxygenation-weighted responses during functional stimulation in a single scan
Ying Cheng 1,2 , Qin Qin 1,3 , Peter C. M. van Zijl 1,3 , James J. Pekar 1,3 , and Jun Hua 1,3
1
F.M. Kirby Research Center for Functional
Brain Imaging, Kennedy Krieger Institute, Baltimore,
Maryland, United States,
2
Dept.
of Biomedical Engineering, Johns Hopkins University,
Baltimore, Maryland, United States,
3
Neurosection,
Div. of MRI Research, Dept. of Radiology and
Radiological Science, Johns Hopkins University,
Baltimore, Maryland, United States
Quantitative approaches have been developed to estimate
CMRO2 dynamics from BOLD, CBF, and CBV responses. The
ability to measure BOLD, CBF, and CBV signals in one
single scan would be useful to improve acquisition
efficiency and reduce temporal variations. We extended
the recently proposed 3D VASO-FAIR approach, which
combines the VASO and FAIR-ASL techniques to
simultaneously detect CBV and CBF responses, with a
T2-preparation module to induce T2-weighted BOLD
contrast, allowing concurrent measurement of BOLD, CBV,
and CBF responses. For visual stimulation, the proposed
method could achieve similar activation patterns, image
quality, tSNR, and CNR as the separate individual scans.
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