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Abstract #0897

Slower DMN, faster reaction: coupling of resting-state CBF and BOLD oscillations in specific frequency bands predicts vigilance task performance

Xiaopeng Song 1 , Shaowen Qian 2 , Kai Liu 2 , Zhenyu Zhou 3 , Gang Sun 2 , and Yijun Liu 1

1 Department of Biomedical Engineering, Peking University, Beijing, Beijing, China, 2 Department of Medical Imaging, Jinan Military General Hospital, Shandong, China, 3 GE Health Care, Beijing, China

We found that subject with slower resting-state BOLD oscillation frequency in DMN reacted faster in psychomotor vigilance test under both normothermic and hyperthermic conditions. CBF mainly contributes to BOLD oscillations of 0.01-0.04Hz under both conditions. The coupling of CBF and BOLD oscillations in 0-0.01Hz and 0.04-0.1Hz were significantly decreased with hyperthermia. Our study linked resting-state brain rhythms to task performance, and for the first time revealed the frequency-specific coupling between blood supply and BOLD oscillation topology during rest and its modulation in response to hyperthermia, which may shed light on the physiological basis of resting-state BOLD activities.

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