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Abstract #0896

Neurochemical and BOLD Responses in Activated Blob and Interblob Neuronal Populations Measured in the Human Visual Cortex at 7T

Petr Bednarik 1,2 , Ivan Tkac 1 , Federico Giove 3,4 , Dinesh Deelchand 1 , Lynn Eberly 1 , Felipe Barreto 1,5 , and Silvia Mangia 1

1 University of Minnesota, Minneapolis, MN, United States, 2 Central European Institute of Technology, Masaryk University, Brno, Czech Republic, 3 MARBILab c/o Fondazione Santa Lucia, "Enrico Fermi" Centre, Rome, Italy, 4 ", Department of Physics - G1 Group, University of Rome "La Sapienza", Rome, Italy, 5 Physics Department, University of Sao Paulo, Sao Paulo, Brazil

Different functional metabolisms might be expected in selectively activated blob and interblob neuronal populations due to different cytochrome-oxidase contents. Here we acquired fMRI and fMRS data during chromatic and achromatic visual stimuli, which selectively activate blob and interblob neurons, respectively. Neurochemical and fMRI-BOLD responses were measured from 12 subjects, each scanned twice. We observed robust BOLD-fMRI signals as well as functional changes in concentration of Glu, Lac, Asp and Glc for both stimuli. No significant differences in neurochemical and BOLD responses between chromatic and achromatic stimuli were found, consistent with equal aerobic responses in blob and interblob neuronal populations.

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