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Abstract #0895

Quantitative and Simultaneous Imaging of CMRO 2 , CBF and OEF in Resting Human Brain

Xiao-Hong Zhu 1 , Hannes M Wiesner 1 , Byeong-Yeul Lee 1 , Ming Lu 1 , Kamil Ugurbil 1 , and Wei Chen 1

1 CMRR, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN, United States

The ability to noninvasively imaging the cerebral metabolic rate of oxygen (CMRO 2 ) is essential for studying oxygen metabolism and its roles in human brain function and dysfunction. We have recently established an in vivo 17 O-MR based approach incorporated with a simple breathing test and a sophisticated quantification model capable of quantitative and simultaneous imaging of three important physiology parameters of CMRO 2 , cerebral blood flow (CBF) and oxygen extraction factor (OEF) in the human brain via a brief 17 O-labeled oxygen gas inhalation. In the present study, we apply this approach to study these parameters and their correlations in the resting brains of healthy human volunteers and the inter- and/or intra-subject variations at 7 Tesla. We found that the resting state CMRO 2 , CBF and OEF values were in good agreement with the literature; they also varied in different subjects, brain tissues and regions. A strong dependence of CMRO 2 on gray matter fraction, a positive correlation between CMRO 2 and CBF, and a negative correlation between CBF and OEF were consistently observed in all subjects studied. The overall findings indicate that the 17 O-MR based approach provides a robust and quantitative neuroimaging tool for noninvasive assessment of CMRO 2 , CBF and OEF in healthy and diseased human brains.

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