Abstract #0895
Quantitative and Simultaneous Imaging of CMRO 2 , CBF and OEF in Resting Human Brain
Xiao-Hong Zhu 1 , Hannes M Wiesner 1 , Byeong-Yeul Lee 1 , Ming Lu 1 , Kamil Ugurbil 1 , and Wei Chen 1
1
CMRR, Department of Radiology, University of
Minnesota Medical School, Minneapolis, MN, United States
The ability to noninvasively imaging the cerebral
metabolic rate of oxygen (CMRO
2
) is essential
for studying oxygen metabolism and its roles in human
brain function and dysfunction. We have recently
established an
in
vivo
17
O-MR
based approach incorporated with a simple breathing test
and a sophisticated quantification model capable of
quantitative and simultaneous imaging of three important
physiology parameters of CMRO
2
, cerebral
blood flow (CBF) and oxygen extraction factor (OEF) in
the human brain via a brief
17
O-labeled
oxygen gas inhalation. In the present study, we apply
this approach to study these parameters and their
correlations in the resting brains of healthy human
volunteers and the inter- and/or intra-subject
variations at 7 Tesla. We found that the resting state
CMRO
2
, CBF and OEF values were in good
agreement with the literature; they also varied in
different subjects, brain tissues and regions. A strong
dependence of CMRO
2
on
gray matter fraction, a positive correlation between
CMRO
2
and
CBF, and a negative correlation between CBF and OEF were
consistently observed in all subjects studied. The
overall findings indicate that the
17
O-MR
based approach provides a robust and quantitative
neuroimaging tool for noninvasive assessment of CMRO
2
,
CBF and OEF in healthy and diseased human brains.
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