Optimization of Oxygen Extraction Fraction Mapping using Joint Parametric Estimation
Youngkyoo Jung 1,2 , Naeim Bahrami 2 , and Megan E Johnston 2
Radiology, Wake Forest School of Medicine,
Winston-Salem, North Carolina, United States,
Engineering, Wake Forest School of Medicine,
Winston-Salem, North Carolina, United States
Oxygen extraction fraction (OEF) is an important
indicator of the oxygen metabolism in the brain.
Currently there are two approaches to measure or map OEF
in the brain using MRI; one approach uses the T2 of
venous blood, while the other uses the magnetic
susceptibility difference between tissue and blood. We
introduce a novel OEF estimation method using the joint
information of T2 and the magnetic susceptibility
difference of blood signal, and present voxel-wise CMRO2
mapping in conjunction with CBF measured with an
arterial spin labeling method. A breath-hold paradigm
was performed to test the feasibility of the algorithm.
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