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Abstract #0894

Optimization of Oxygen Extraction Fraction Mapping using Joint Parametric Estimation

Youngkyoo Jung 1,2 , Naeim Bahrami 2 , and Megan E Johnston 2

1 Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States, 2 Biomedical Engineering, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States

Oxygen extraction fraction (OEF) is an important indicator of the oxygen metabolism in the brain. Currently there are two approaches to measure or map OEF in the brain using MRI; one approach uses the T2 of venous blood, while the other uses the magnetic susceptibility difference between tissue and blood. We introduce a novel OEF estimation method using the joint information of T2 and the magnetic susceptibility difference of blood signal, and present voxel-wise CMRO2 mapping in conjunction with CBF measured with an arterial spin labeling method. A breath-hold paradigm was performed to test the feasibility of the algorithm.

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