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Abstract #0893

Exploring human brain oxidative metabolism and neurotransmitter cycling via coupled 13C MRS at 7T

Vikram Jakkamsetti 1 , Levi Good 1 , Dorothy Kelly 1 , Sergey Cheshkov 2 , Karthik Rajasekaran 1 , Dean Sherry 2 , Juan Pascual 1 , Craig Malloy 2 , and Ivan Dimitrov 2,3

1 Neurology and Neurotherapeutics, UT Southwestern Medical Center, Dallas, TX, United States, 2 Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 3 Philips Medical Systems, Cleveland, Ohio, United States

13C NMR spectra measure the rate of energy production in vivo for human brains, but require prolonged 90120 min infusions in the magnet which is difficult for patients with brain disorders. We infused 13C-enriched glucose to steady-state outside the magnet followed by an hour of 13C NMR spectroscopy at 7T without 1H decoupling. We report stable (for at least 60 min) and distinctly identified signals for spin-coupled doublet D45 and natural abundance singlet in glutamate C5, a prominent 13C- bicarbonate signal and essentially undetectable alanine and lactate.

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