Abstract #0893
Exploring human brain oxidative metabolism and neurotransmitter cycling via coupled 13C MRS at 7T
Vikram Jakkamsetti 1 , Levi Good 1 , Dorothy Kelly 1 , Sergey Cheshkov 2 , Karthik Rajasekaran 1 , Dean Sherry 2 , Juan Pascual 1 , Craig Malloy 2 , and Ivan Dimitrov 2,3
1
Neurology and Neurotherapeutics, UT
Southwestern Medical Center, Dallas, TX, United States,
2
Advanced
Imaging Research Center, UT Southwestern Medical Center,
Dallas, TX, United States,
3
Philips
Medical Systems, Cleveland, Ohio, United States
13C NMR spectra measure the rate of energy production in
vivo for human brains, but require prolonged 90120 min
infusions in the magnet which is difficult for patients
with brain disorders. We infused 13C-enriched glucose to
steady-state outside the magnet followed by an hour of
13C NMR spectroscopy at 7T without 1H decoupling. We
report stable (for at least 60 min) and distinctly
identified signals for spin-coupled doublet D45 and
natural abundance singlet in glutamate C5, a prominent
13C- bicarbonate signal and essentially undetectable
alanine and lactate.
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