Iron and Non-iron Related Pathological Features of Multiple Sclerosis Lesions using Multiparametric 7T MRI
Sanjeev Chawla 1 , Ilya Kister 2 , Jens Wuerfel 3 , E Mark Haacke 4 , Tim Sinnecker 3 , Jean Christophe Brisset 1 , Friedemann Paul 3 , and Yulin Ge 1
Radiology, New York University Langone
Medical Center, New York, NY, United States,
New York University Langone Medical Center, New York,
NY, United States,
Universittsmedizin Gttingen, Berlin, Germany,
Wayne State University, Detroit, Michigan, United States
To characterize multiple sclerosis (MS) lesions based on
iron and non-iron related pathological features,
twenty-one patients underwent GRE-T2* and
high-resolution quantitative susceptibility mapping (QSM)
imaging on 7T MR system. Three morphologically distinct
lesion patterns were observed. Majority of the lesions
(75.0%), were hyperintense on T2* images and
inconspicuous on QSM (Pattern A), few lesions (9.56%)
showed hyperintensity on both T2* and QSM (Pattern B).
However, some lesions (15.5%) demonstrated hypointensity
on T2*/SWI images and hyperintensity on QSM (Pattern C)
indicating that that these lesions encompass predominant
iron content. Ultra-high field MRI may provide insights
into the pathogenesis of MS lesions.
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