Abstract #0903
Iron and Non-iron Related Pathological Features of Multiple Sclerosis Lesions using Multiparametric 7T MRI
Sanjeev Chawla 1 , Ilya Kister 2 , Jens Wuerfel 3 , E Mark Haacke 4 , Tim Sinnecker 3 , Jean Christophe Brisset 1 , Friedemann Paul 3 , and Yulin Ge 1
1
Radiology, New York University Langone
Medical Center, New York, NY, United States,
2
Neurology,
New York University Langone Medical Center, New York,
NY, United States,
3
Radiology,
Universittsmedizin Gttingen, Berlin, Germany,
4
Radiology,
Wayne State University, Detroit, Michigan, United States
To characterize multiple sclerosis (MS) lesions based on
iron and non-iron related pathological features,
twenty-one patients underwent GRE-T2* and
high-resolution quantitative susceptibility mapping (QSM)
imaging on 7T MR system. Three morphologically distinct
lesion patterns were observed. Majority of the lesions
(75.0%), were hyperintense on T2* images and
inconspicuous on QSM (Pattern A), few lesions (9.56%)
showed hyperintensity on both T2* and QSM (Pattern B).
However, some lesions (15.5%) demonstrated hypointensity
on T2*/SWI images and hyperintensity on QSM (Pattern C)
indicating that that these lesions encompass predominant
iron content. Ultra-high field MRI may provide insights
into the pathogenesis of MS lesions.
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