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Abstract #0904

Impact of intra- and juxta-cortical pathology on cognitive impairment in multiple sclerosis by quantitative T 2 * mapping at 7 T MRI

Cline Louapre 1 , Sindhuja T Govindarajan 1 , Costanza Giann 1 , Nancy Madigan 2 , AS Nielsen 3 , RP Kinkel 4 , and Caterina Mainero 1

1 AA. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2 Beth Israel Deaconess Medical Center, Boston, MA, United States, 3 Virginia Mason Medical Center, Seattle, WA, United States, 4 University of California San Diego, San Diego, CA, United States

This study aims at determining the relation between nueropsychological performance in patients with multiple sclerosis and cortical tissue damage at different depths through the cortical width up to the juxta-cortical white matter, across the whole brain. Therefore, we use a quantitative, surface-based analysis of T 2 * relaxation rates from ultra high resolution 7 Tesla MRI.

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