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Abstract #0906

USPIO Contrast Enhanced MRI Study Monitoring Inflammatory Lesions in Brain of the Relapsing-Remitting Model of EAE in SJL/J mice

Matthew Fronheiser 1 , Jenny Xie 1 , Elizabeth Heimrich 1 , Adrienne Pena 1 , Thomas Petrone 1 , Daniel Kukral 1 , Vojkan Susulic 1 , Harold Malone 1 , Patrick Chow 1 , Shuyan Du 1 , Feng Lu 1 , Wendy Hayes 1 , and Haiying Tang 1

1 Bristol Myers Squibb, Princeton, New Jersey, United States

In this work, ultrasmall superparamagnetic iron oxide (USPIO) nanoparticle enhanced MRI techniques were used to assess brain inflammatory lesions in a mouse model of Relapsing-Remitting multiple sclerosis (MS). Three groups (No disease, Disease No Treatment, Disease Treatment) were studied at four time points to monitor the relapsing and remitting phases of the disease. Pixel-wise R2 and Change in R2 (ΔR2) maps were generated to evaluate regions of increased USPIO uptake in the brain. Our results showed that USPIO enhanced MRI can be used to assess changes in the inflammatory lesion to examine treatment effect in a MS mouse model.

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