Meeting Banner
Abstract #0907

Connectivity-based parcellation of the thalamus in multiple sclerosis and its implications for cognitive impairment: a multicenter study

Elisabetta Pagani 1 , Maria A. Rocca 1,2 , Alvino Bisecco 1 , Laura Mancini 3 , Christian Enzinger 4 , Antonio Gallo 5 , Hugo Vrenken 6 , Maria Laura Stromillo 7 , Massimiliano Copetti 1 , David Thomas 3 , Franz Fazekas 4 , Gioacchino Tedeschi 5 , Frederik Barkhof 6 , Nicola De Stefano 7 , Massimo Filippi 1,2 , and for the MAGNIMS Network 8

1 Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, MI, Italy, 2 Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, MI, Italy, 3 UCLH NHS Foundation Trust, National Hospital for Neurology and Neurosurgery, London, UK, United Kingdom, 4 Department of Neurology, Medical University of Graz, Graz, A, Austria, 5 MRI Center SUN-FISM", Second University of Naples, Naples, NA, Italy, 6 Department of Radiology, VU University Medical Centre, Amsterdam, Netherlands, Netherlands, 7 Department of Neurological and Behavioral Sciences, University of Siena, Siena, SI, Italy, 8 EU, EU, Italy

The thalamus is a complex structure, organized in nuclear groups with specific functions and connections with cortical and subcortical areas. This is why studying the whole thalamus could be inadequate to explain deficits of specific functions. In this multicenter study, we performed tractography-based parcellation of the thalamus and its white matter connections to investigate the relationship between thalamic connectivity abnormalities and cognitive impairment in multiple sclerosis (MS). Cognitive impaired patients had more relevant microstructural damage of motor, post-central and occipital connected thalamic regions, reflecting prominent gray matter damage. Cortico-thalamic disconnection is, at various levels, implicated in cognitive dysfunction in MS.

This abstract and the presentation materials are available to members only; a login is required.

Join Here