Abstract #0907
Connectivity-based parcellation of the thalamus in multiple sclerosis and its implications for cognitive impairment: a multicenter study
Elisabetta Pagani 1 , Maria A. Rocca 1,2 , Alvino Bisecco 1 , Laura Mancini 3 , Christian Enzinger 4 , Antonio Gallo 5 , Hugo Vrenken 6 , Maria Laura Stromillo 7 , Massimiliano Copetti 1 , David Thomas 3 , Franz Fazekas 4 , Gioacchino Tedeschi 5 , Frederik Barkhof 6 , Nicola De Stefano 7 , Massimo Filippi 1,2 , and for the MAGNIMS Network 8
1
Neuroimaging Research Unit, Institute of
Experimental Neurology, Division of Neuroscience, San
Raffaele Scientific Institute, Vita-Salute San Raffaele
University, Milan, MI, Italy,
2
Department
of Neurology, San Raffaele Scientific Institute,
Vita-Salute San Raffaele University, Milan, MI, Italy,
3
UCLH
NHS Foundation Trust, National Hospital for Neurology
and Neurosurgery, London, UK, United Kingdom,
4
Department
of Neurology, Medical University of Graz, Graz, A,
Austria,
5
MRI
Center SUN-FISM", Second University of Naples, Naples,
NA, Italy,
6
Department
of Radiology, VU University Medical Centre, Amsterdam,
Netherlands, Netherlands,
7
Department
of Neurological and Behavioral Sciences, University of
Siena, Siena, SI, Italy,
8
EU,
EU, Italy
The thalamus is a complex structure, organized in
nuclear groups with specific functions and connections
with cortical and subcortical areas. This is why
studying the whole thalamus could be inadequate to
explain deficits of specific functions. In this
multicenter study, we performed tractography-based
parcellation of the thalamus and its white matter
connections to investigate the relationship between
thalamic connectivity abnormalities and cognitive
impairment in multiple sclerosis (MS). Cognitive
impaired patients had more relevant microstructural
damage of motor, post-central and occipital connected
thalamic regions, reflecting prominent gray matter
damage. Cortico-thalamic disconnection is, at various
levels, implicated in cognitive dysfunction in MS.
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