Abstract #0908
Hippocampal-related memory network in Multiple Sclerosis: a structural connectivity analysis
Elisabetta Pagani 1 , Maria A. Rocca 1,2 , Sara Llufriu 1,3 , Gianna Carla Riccitelli 1 , Bruno Colombo 2 , Mariaemma Rodegher 2 , Andrea Falini 4 , Giancarlo Comi 2 , and Massimo Filippi 1,2
1
Neuroimaging Research Unit, Institute of
Experimental Neurology, Division of Neuroscience, San
Raffaele Scientific Institute, Vita-Salute San Raffaele
University, Milan, MI, Italy,
2
Department
of Neurology, San Raffaele Scientific Institute,
Vita-Salute San Raffaele University, Milan, MI, Italy,
3
Hospital
Clinic Barcelona, Barcelona, E, Spain,
4
Department
of Neuroradiology, San Raffaele Scientific Institute,
Vita-Salute San Raffaele University, Milan, MI, Italy
Memory dysfunction is frequently present in patients
with multiple sclerosis and diffusion tensor imaging
enables to define and quantify structural damage in
networks involved in memory performance. In this study,
we quantified structural connectivity integrity of the
hippocampal-related episodic memory network and its
association with memory performance in multiple
sclerosis patients. We found that the network is
globally impaired in patients, even if it maintains a
configuration in which the thalamus and parietal lobes
show the highest strength. The integrity of this network
seems relevant for preserving memory functions.
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