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Abstract #0911

BOLD, Blood Flow and Hypercapnic Challenge Reveals Cerebrovascular Decoupling in Multiple Sclerosis

Mark J. Lowe 1 , Wanyong Shin 1 , Lael Stone 2 , Robert Bermel 2 , and Micheal D. Phillips 1

1 Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, 2 Neurologic Insititute, Cleveland Clinic, Cleveland, OH, United States

It is known that multiple sclerosis results in decreased cerebral metabolic rate of oxygen and blood flow. Both of these are critical elements in cerebrovascular reactivity to neuronal activation. Using simultaneous BOLD/ASL, we measured BOLD activation during a visual task and cerebrovascular reactivity using a hypercapnia challenge in a cohort of multiple sclerosis patients and matched control subjects. We show that the cerebrovascular coupling is significantly different in multiple sclerosis patients.

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