Abstract #0932
Bound Bone Water Density is a Surrogate Measurement of Organic Matrix Density
Alan C. Seifert 1 , Cheng Li 1 , Suzanne L. Wehrli 2 , and Felix W. Wehrli 1
1
University of Pennsylvania, Philadelphia,
PA, United States,
2
Children's
Hospital of Philadelphia, Philadelphia, PA, United
States
Proton NMR signal in bone arises from pore water (T2 >
1ms), bound water (T2 ~ 400100s), and collagen (T2 <<
100s). Pore water is hypothesized to scale with
porosity, and bound water with collagen density. Here we
measured single adiabatic inversion-recovery zero
echo-time (SIR-ZTE) bound water density in 15 human
cortical bone specimens at 9.4T, and found strong
correlations with both gravimetric organic matrix
density (R^2 = 0.74) and CT porosity (R^2 = 0.73). SIR-ZTE
is therefore suitable for measurement of matrix density
in vivo.
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