Meeting Banner
Abstract #0932

Bound Bone Water Density is a Surrogate Measurement of Organic Matrix Density

Alan C. Seifert 1 , Cheng Li 1 , Suzanne L. Wehrli 2 , and Felix W. Wehrli 1

1 University of Pennsylvania, Philadelphia, PA, United States, 2 Children's Hospital of Philadelphia, Philadelphia, PA, United States

Proton NMR signal in bone arises from pore water (T2 > 1ms), bound water (T2 ~ 400100s), and collagen (T2 << 100s). Pore water is hypothesized to scale with porosity, and bound water with collagen density. Here we measured single adiabatic inversion-recovery zero echo-time (SIR-ZTE) bound water density in 15 human cortical bone specimens at 9.4T, and found strong correlations with both gravimetric organic matrix density (R^2 = 0.74) and CT porosity (R^2 = 0.73). SIR-ZTE is therefore suitable for measurement of matrix density in vivo.

This abstract and the presentation materials are available to members only; a login is required.

Join Here