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Abstract #0933

In vivo imaging of bound and pore water in tibia and femur using 3D Cones sequences

Jun Chen 1 , Michael Carl 2 , Hongda Shao 1 , Soorena Azam Zanganeh 1 , Eric Chang 1,3 , Christine B Chung 1,3 , Graeme M Bydder 1 , and Jiang Du 1

1 Radiology, University of California, San Diego, CA, United States, 2 GE Healthcare, San Diego, CA, United States, 3 Department of Radiology, VA San Diego Healthcare System, San Diego, CA, United States

Bound and pore water have been reported to make different contributions to the mechanical properties of cortical bone. By using Ultrashort echo time (UTE) sequences signals from both bound and pore water can be detected in cortical bone. In this study, tibial and femoral mid-shafts in healthy volunteers were respectively imaged with 3D Cones and 3D IR-Cones sequences, to measure T1 and T2* of bound and pore water at both sites, and to investigate whether there are differences between these two sites. High resolution imaging of the tibia and fermur can be achieved. The femoral midshaft and tibial midshaft have different MR properties, including bound and pore water T2*s, relative fractions, effective T1 of both bound and pore water, and T1 of bound water.This study suggests that T1 and T2* of bound and pore water in cortical bone can be measured with 3D Cones and IR-Cones sequences; femoral and tibial midshafts may have different properties in healthy volunteers.

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