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Abstract #0939

MRS-based vertebral bone marrow fat quantification using prior fat spectrum characterization and T2 correction

Michael Dieckmeyer 1 , Stefan Ruschke 1 , Christian Cordes 1 , Samuel Paran Yap 1 , Hendrik Kooijman 2 , Hans Hauner 1 , Ernst J. Rummeny 1 , Jan S. Bauer 1 , Thomas Baum 1 , and Dimitrios C. Karampinos 1

1 Technische Universitt Mnchen, Munich, Germany, 2 Philips Healthcare, Germany

MRS-based vertebral bone marrow fat quantification is confounded by the overlapping of water and fat peaks and the differences in T 2 relaxation times of water and fat. The purpose of the present study was to determine using single-voxel MRS the vertebral bone marrow proton density fat fraction (PDFF) using single-voxel MRS, addressing the confounding effects introduced by overlapping water-fat peaks and the difference in T 2 relaxation time between the water and fat components. The importance of the consideration of T 2 decay effects in bone marrow fat quantification was shown in the context of the analysis of the bone marrow fat fraction age dependence.

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