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Abstract #0942

Prostate MRSI Predicts Treatment Failure after Radical Prostatectomy

Kristen Zakian 1 , William Hatfield 2 , Omer Aras 2 , Kun Cao 3 , Derya Yakar 4 , Debra Goldman 2 , Chaya Moskowitz 2 , Amita Shukla-Dave 2 , Yousef Mazaheri Tehrani 2 , Samson Fine 2 , James Eastham 2 , and Hedvig Hricak 2

1 Memorial Sloan-Kettering Cancer Center, New York, NY, United States, 2 MSKCC, NY, United States, 3 Peking University Cancer Hospital, Beijing, China, 4 Radboud University of Nijmegen Medical Centre, Nijmegen, Netherlands

The value of prostate cancer metabolic data for predicting clinical outcome is of high clinical interest. In the current study, we sought to confirm the prognostic potential of 1H-MRSI in a large surgical population with long-term followup. We examined data from 262 subjects who underwent endorectal MRI/MRSI followed by radical prostatectomy from 2003-2007. The data indicate that the volume of metabolic abnormality detected by MRSI is correlated with treatment failure and is an independent predictor of failure in a multivariate analysis which includes an NCCN-based clinical risk score and the number of positive biopsy cores.

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