Abstract #0942
Prostate MRSI Predicts Treatment Failure after Radical Prostatectomy
Kristen Zakian 1 , William Hatfield 2 , Omer Aras 2 , Kun Cao 3 , Derya Yakar 4 , Debra Goldman 2 , Chaya Moskowitz 2 , Amita Shukla-Dave 2 , Yousef Mazaheri Tehrani 2 , Samson Fine 2 , James Eastham 2 , and Hedvig Hricak 2
1
Memorial Sloan-Kettering Cancer Center, New
York, NY, United States,
2
MSKCC,
NY, United States,
3
Peking
University Cancer Hospital, Beijing, China,
4
Radboud
University of Nijmegen Medical Centre, Nijmegen,
Netherlands
The value of prostate cancer metabolic data for
predicting clinical outcome is of high clinical
interest. In the current study, we sought to confirm the
prognostic potential of 1H-MRSI in a large surgical
population with long-term followup. We examined data
from 262 subjects who underwent endorectal MRI/MRSI
followed by radical prostatectomy from 2003-2007. The
data indicate that the volume of metabolic abnormality
detected by MRSI is correlated with treatment failure
and is an independent predictor of failure in a
multivariate analysis which includes an NCCN-based
clinical risk score and the number of positive biopsy
cores.
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