X-ray Fluorescence Microscopy Imaging of the Normal Mouse Prostate Reveals that Intravenously Administered Gadolinium Enters the Lumen of the Prostatic Glands
Devkumar Mustafi 1 , Sophie-Charlotte Gleber 2 , Urszula Dougherty 3 , Marta Zamora 1 , Tatjana Antic 4 , Stefan Vogt 2 , Gregory S Karczmar 1 , and Aytekin Oto 1
Radiology, The University of Chicago,
Chicago, IL, United States,
Proton Source, Argonne National Laboratory, Lemont, IL,
Medicine, The University of
Chicago, Chicago, IL, United States,
The University of Chicago, Chicago, IL, United States
DCE-MRI is a standard component of multi-parametric
prostate MRI protocols. Analysis of DCE-MRI data from
prostate is usually based on the model that gadolinium
distributes into two well-mixed compartments and assumes
that gadolinium does not enter into the glandular lumen.
However, this assumption has not been directly tested.
The purpose of our study was to measure concentrations
of gadolinium in the prostatic epithelia and lumens of
the normal mouse following intravenous injection, using
X-ray fluorescence microscopy imaging. We have
quantitatively determined gadolinium distributions in
mouse prostatic epithelia and lumens and demonstrated
that intravenously administered gadolinium enters into
mouse prostatic lumens.
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