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Abstract #0943

X-ray Fluorescence Microscopy Imaging of the Normal Mouse Prostate Reveals that Intravenously Administered Gadolinium Enters the Lumen of the Prostatic Glands

Devkumar Mustafi 1 , Sophie-Charlotte Gleber 2 , Urszula Dougherty 3 , Marta Zamora 1 , Tatjana Antic 4 , Stefan Vogt 2 , Gregory S Karczmar 1 , and Aytekin Oto 1

1 Radiology, The University of Chicago, Chicago, IL, United States, 2 Advanced Proton Source, Argonne National Laboratory, Lemont, IL, United States, 3 Medicine, The University of Chicago, Chicago, IL, United States, 4 Pathology, The University of Chicago, Chicago, IL, United States

DCE-MRI is a standard component of multi-parametric prostate MRI protocols. Analysis of DCE-MRI data from prostate is usually based on the model that gadolinium distributes into two well-mixed compartments and assumes that gadolinium does not enter into the glandular lumen. However, this assumption has not been directly tested. The purpose of our study was to measure concentrations of gadolinium in the prostatic epithelia and lumens of the normal mouse following intravenous injection, using X-ray fluorescence microscopy imaging. We have quantitatively determined gadolinium distributions in mouse prostatic epithelia and lumens and demonstrated that intravenously administered gadolinium enters into mouse prostatic lumens.

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