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Abstract #0944

Two-compartment T2 Decay for Prostate Cancer Diagnosis

Shiyang Wang 1 , Harsh Agarwal 2 , Gregory S. Karczmar 1 , and Aytek Oto 1

1 Radiology, University of Chicago, Chicago, IL, United States, 2 Clinical Research Development, Philips Research North America, Briarcliff, Manor, NY, United States

Accurate modeling of T2 decay in prostate may improve the prostate cancer detection. Glandular structure of prostate suggests multi-compartment T2 decay of prostate. In this manuscript multi-echo TSE MRI over TE=24 to 396msec was acquired and fitted to mono and bi-exponential T2 decay models. Individual parameters from mono and bi exponential fitting were able to show significant difference between cancer and normal prostate tissue. An accelerated ME-TSE is repeated twice and compared with un-accelerated ME-TSE MRI showed that accelerated ME-TSE is accurate but is less precise may be due to lower SNR.

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