Abstract #0945
Gestational age dependent increase in placental perfusion quantified using MRI
Brijesh Kumar Yadav 1,2 , Jaladhar Neelavalli 1,2 , Uday Krishnamurthy 1,2 , Yimin Shen 2 , Gabor Szalai 3 , Bing Wang 3 , Tinnakorn Chaiworapongsa 3,4 , Edgar Hernandez Andrade 3,4 , Nandor Gabor Than 3,4 , Ewart Mark Haacke 1,2 , and Roberto Romero 3
1
Department of Biomedical Engineering, Wayne
State University, Detroit, Michigan, United States,
2
Department
of Radiology, Wayne State University, Detroit, Michigan,
United States,
3
Perinatology
Research Branch, NICHD, NIH, DHHS, Wayne State
University, Detroit, Michigan, United States,
4
Department
of Obstetrics and Gynecology, Wayne State University,
Detroit, Michigan, United States
Placental insufficiency is one of the leading causes of
abnormal materno-fetal circulation which could lead to
intrauterine growth restriction. The placenta is a
dynamic structure which changes with the gestational
age. Hence understanding the natural course of placental
perfusion characteristics in normal mice pregnancy is
critical to contrast it with changes that occur in the
different pathologies at different gestational ages.
This study reports the quantification of longitudinal
variations in perfusion characteristics of the high and
low blood perfusion compartments of normal murine
placenta using DCE MRI.
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