Abstract #0951
In vivo MRI assessment of hepato-splenic disease in a murine model of schistosmiasis
Brice Masi 1,2 , Teodora-Adriana Perles-Barbacaru 3,4 , Caroline Laprie 5 , Helia Dessein 1,2 , Monique Bernard 3,4 , Alain Dessein 1,2 , and Angle Viola 3,4
1
INSERM U906, Marseille, France,
2
GIMP
UMR_S 906, Aix-Marseille Universit, Marseille, France,
3
CRMBM
UMR CNRS 7339, Marseille, France,
4
Aix-Marseille
Universit, Marseille, France,
5
Laboratoire
VET-HISTO, Marseille, France
Schistosomiasis, a tropical parasitic infection, often
leads to fatal liver fibrosis. The hepatosplenic disease
in a mouse model of schistosomiasis is studied
in
vivo
by
high resolution volumetric MRI and quantitative T
2
-mapping.
As early as 6 weeks after infestation, MRI reveals
hepato- and splenomegaly, as well as portal
hypertension. At 10 weeks, multifocal lesions with
increased T
2
appear
on MRI. The area fraction of increased T
2
in
the livers correlates with the area fraction of fibrotic
tissue revealed with sirius red staining. This
multimodal MRI approach assesses hepatosplenic disease
and liver fibrosis non-invasively and is useful for
treatment monitoring.
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