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Abstract #0951

In vivo MRI assessment of hepato-splenic disease in a murine model of schistosmiasis

Brice Masi 1,2 , Teodora-Adriana Perles-Barbacaru 3,4 , Caroline Laprie 5 , Helia Dessein 1,2 , Monique Bernard 3,4 , Alain Dessein 1,2 , and Angle Viola 3,4

1 INSERM U906, Marseille, France, 2 GIMP UMR_S 906, Aix-Marseille Universit, Marseille, France, 3 CRMBM UMR CNRS 7339, Marseille, France, 4 Aix-Marseille Universit, Marseille, France, 5 Laboratoire VET-HISTO, Marseille, France

Schistosomiasis, a tropical parasitic infection, often leads to fatal liver fibrosis. The hepatosplenic disease in a mouse model of schistosomiasis is studied in vivo by high resolution volumetric MRI and quantitative T 2 -mapping. As early as 6 weeks after infestation, MRI reveals hepato- and splenomegaly, as well as portal hypertension. At 10 weeks, multifocal lesions with increased T 2 appear on MRI. The area fraction of increased T 2 in the livers correlates with the area fraction of fibrotic tissue revealed with sirius red staining. This multimodal MRI approach assesses hepatosplenic disease and liver fibrosis non-invasively and is useful for treatment monitoring.

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