Abstract #0963
Enhanced T1-weighted myelin contrast across lamina at 7T; in-vivo, ex-vivo, and histology
Alessio Fracasso 1 , Susanne J van Veluw 2 , Fredy Visser 3,4 , Jaco JM Zwanenburg 4 , Serge O Dumoulin 1 , and Natalia Petridou 4
1
Experimental Psychology, Helmholtz
institute, Utrecht University, Utrecht, Netherlands,
2
Neurology,
Brain Center Rudolf Magnus, University Medical Center,
Utrecht, Netherlands,
3
Philips
Medical Systems, Best, Netherlands,
4
Radiology,
Imaging Division, University Medical Center, Utrecht,
Netherlands
Myelin content can be estimated in vivo to identify a
large number of cortical areas, however extra-striate,
within-area myelination at sub-mm scale is harder to
visualize. Using a modified T1-w MPRAGE we visualize
striate and extra-striate laminar intensity variations
in in-vivo and ex-vivo data, comparing ex-vivo results
with histological sections. In-vivo, ex-vivo and
histology striate areas as well extra-striate cortex
showed a reliable, high-contrast structure around the
middle of cortical thickness in T1-w laminar profiles.
This structure likely represents the two separated lines
of Baillarger. This T1-w sequence provides the basis for
studying laminar structure in humans, in vivo.
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