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Abstract #0963

Enhanced T1-weighted myelin contrast across lamina at 7T; in-vivo, ex-vivo, and histology

Alessio Fracasso 1 , Susanne J van Veluw 2 , Fredy Visser 3,4 , Jaco JM Zwanenburg 4 , Serge O Dumoulin 1 , and Natalia Petridou 4

1 Experimental Psychology, Helmholtz institute, Utrecht University, Utrecht, Netherlands, 2 Neurology, Brain Center Rudolf Magnus, University Medical Center, Utrecht, Netherlands, 3 Philips Medical Systems, Best, Netherlands, 4 Radiology, Imaging Division, University Medical Center, Utrecht, Netherlands

Myelin content can be estimated in vivo to identify a large number of cortical areas, however extra-striate, within-area myelination at sub-mm scale is harder to visualize. Using a modified T1-w MPRAGE we visualize striate and extra-striate laminar intensity variations in in-vivo and ex-vivo data, comparing ex-vivo results with histological sections. In-vivo, ex-vivo and histology striate areas as well extra-striate cortex showed a reliable, high-contrast structure around the middle of cortical thickness in T1-w laminar profiles. This structure likely represents the two separated lines of Baillarger. This T1-w sequence provides the basis for studying laminar structure in humans, in vivo.

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