Abstract #0978
Quantitative Evaluation of Emphysema in COPD Patients via CT and UTE MR Image Analysis
David J. Roach 1,2 , Yannick Crmillieux 3 , Suraj Serai 4 , Robert Thomen 1,5 , Sadia Benzaquen 6 , and Jason C. Woods 1,2
1
Center for Pulmonary Imaging Research,
Cincinnati Childrens Hospital Medical Center,
Cincinnati, Ohio, United States,
2
Pulmonary
Medicine, Cincinnati Childrens Hospital Medical Center,
Cincinnati, Ohio, United States,
3
Centre
de Rsonance Magntique des Systmes Biologiques,
Universit de Bordeaux, Bordeaux, France,
4
Radiology,
Cincinnati Childrens Hospital Medical Center,
Cincinnati, Ohio, United States,
5
Physics,
Washington University in St. Louis, St. Louis, Missouri,
United States,
6
University
of Cincinnati College of Medicine, Cincinnati, Ohio,
United States
We investigated whether lung ultrashort echo-time (UTE)
MRI could generate quantitative imaging biomarkers for
patients diagnosed with chronic obstructive pulmonary
disease (COPD). COPD patients and control subjects were
imaged via UTE MRI; these images were compared to chest
CTs, both qualitatively and quantitatively. UTE MRI
signal intensity was lower in the COPD group (p<0.001)
and emphysema index (EI) was higher (p<0.006). EI of MRI
correlated well with EI calculated via CT (R2=0.82).
This study demonstrates that UTE MRI can be employed to
quantify tissue destruction in emphysema patients, and
can potentially assess COPD extent and severity.
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