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Abstract #0977

Tobacco smoke exposure reduces lung T 1 in COPD patients

Daniel F Alamidi 1 , Alexandra R Morgan 2,3 , Penny L Hubbard Cristinacce 3 , Lars H Nordenmark 4 , Paul D Hockings 4,5 , Kerstin M Lagerstrand 1 , Simon S Young 6 , Josephine H Naish 3 , John C Waterton 3,6 , Lars E Olsson 7 , and Geoff J.M Parker 2,3

1 Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden, 2 Bioxydyn Ltd, Manchester, United Kingdom, 3 Centre for Imaging Sciences and Biomedical Imaging Institute, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom, 4 AstraZeneca R&D, Mlndal, Sweden, 5 Chalmers University of Technology, MedTech West, Gothenburg, Sweden, 6 AstraZeneca R&D, Alderley Park, United Kingdom, 7 Department of Medical Physics, Lund University, Lund, Sweden

Cigarette smoking is the primary cause of COPD. MRI may improve disease characterization with new lung function assessments where often T1 measurements are included. We investigated whether tobacco smoke exposure affects lung T1 in COPD patients. Free breathing T1 measurements were performed in 23 COPD smokers and 11 healthy age-matched non-smokers. A strong correlation between smoke exposure and T1 was observed, that may be due to smoking-induced lung pathology or the presence of impurities in the lung. Consequently, the smoking history of a patient is an essential factor when T1 is used as a readout in studies of lung diseases.

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