Abstract #0977
Tobacco smoke exposure reduces lung T 1 in COPD patients
Daniel F Alamidi 1 , Alexandra R Morgan 2,3 , Penny L Hubbard Cristinacce 3 , Lars H Nordenmark 4 , Paul D Hockings 4,5 , Kerstin M Lagerstrand 1 , Simon S Young 6 , Josephine H Naish 3 , John C Waterton 3,6 , Lars E Olsson 7 , and Geoff J.M Parker 2,3
1
Department of Radiation Physics, Institute
of Clinical Sciences, Sahlgrenska Academy, University of
Gothenburg, Sweden,
2
Bioxydyn
Ltd, Manchester, United Kingdom,
3
Centre
for Imaging Sciences and Biomedical Imaging Institute,
Manchester Academic Health Sciences Centre, University
of Manchester, Manchester, United Kingdom,
4
AstraZeneca
R&D, Mlndal, Sweden,
5
Chalmers
University of Technology, MedTech West, Gothenburg,
Sweden,
6
AstraZeneca R&D, Alderley Park,
United Kingdom,
7
Department
of Medical Physics, Lund University, Lund, Sweden
Cigarette smoking is the primary cause of COPD. MRI may
improve disease characterization with new lung function
assessments where often T1 measurements are included. We
investigated whether tobacco smoke exposure affects lung
T1 in COPD patients. Free breathing T1 measurements were
performed in 23 COPD smokers and 11 healthy age-matched
non-smokers. A strong correlation between smoke exposure
and T1 was observed, that may be due to smoking-induced
lung pathology or the presence of impurities in the
lung. Consequently, the smoking history of a patient is
an essential factor when T1 is used as a readout in
studies of lung diseases.
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