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Abstract #0982

MR Imaging, targeting and characterization of pulmonary fibrosis using intra-tracheal administration of Gadolinium based nanoparticles

Nawal Tassali 1 , Andrea Bianchi 1 , Franois Lux 2 , Gerard Raffard 1 , Stephane Sanchez 1 , Olivier Tillement 2 , and Yannick Cremillieux 1

1 Centre de Resonance Magnetique des Systemes Biologiques, CNRS UMR 5536, Universite de Bordeaux, Bordeaux, France, 2 Institut Lumire Matire, CNRS UMR 5306, Universite Claude Bernard, Domaine Scientifique de la Doua, Villeurbane, France

Pulmonary fibrosis is a lethal disease and models are critical to develop diagnostic approaches. We investigated here whether MRI combined with gadolinium-based nanoparticles can help visualize and characterize lung fibrosis in mice. Gd-based contrast agent was intra-tracheally administered in bleomycin-treated and in healthy mice and UTE-MRI images were acquired. Signal enhancement (SE), contrast-to-noise ratio (CNR), and pharmacokinetics of the nanoparticles in mice lungs were quantified. A SE of 120%, a twofold increase of CNR and a longer elimination time constant of the nanoparticles were obtained in bleomycin-treated mice. These findings demonstrate new imaging protocols for detecting and characterizing fibrotic tissues.

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