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Abstract #0990

3D MR spectroscopic imaging using adiabatic spin echo and hypergeometric dual band pulses for metabolic mapping over the entire brain

Morteza Esmaeili 1,2 , Tone Frost Bathen 2 , Bruce R. Rosen 1 , and Ovidiu Cristian Andronesi 1

1 Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 2 Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), Trondheim, Norway

Full head proton magnetic resonance spectroscopic imaging (MRSI) is desirable to map metabolites over the entire brain but challenging due to large artifacts created by lipid signals. Hypergeometric dual band pulses have a very sharp passband and when combined with adiabatic spin echo and MEGA editing provide efficient lipid and water suppression for full brain metabolic imaging. Here we show that such a combined approach is robust with respect to B1 inhomogeneity at 3T and is superior to traditional suppression schemes for 3D MRSI of full brain.

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