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Abstract #0991

Detection of brain macromolecules using double inversion recovery ultra-short acquisition delay 1 H MRSI at 7 Tesla

Michal Povaan 1 , Gilbert Hangel 1 , Bernhard Strasser 1 , Marek Chmelik 1 , Stephan Gruber 1 , Siegfried Trattnig 1 , and Wolfgang Bogner 1

1 MRCE, Department of Biomedical Imaging and Image-guided therapy, Medical University Vienna, Vienna, Austria

The 1H ultra-short acquisition delay spectra are characterized by the superposition of signals of metabolites and macromolecules. We have developed a double inversion nulling method to measure macromolecular spectra at 7T with acquisition delay as short as 1.3 ms and very short repetition time (900 ms). Optimal inversion times were simulated and experimentally verified. Macromolecular spectra were acquired from four young healthy volunteers. The spectra did not exhibit any visible difference in inter-subject comparison. In addition, four conventional 1H MRSI datasets without inversion were acquired in healthy subjects and quantified using basis sets with and without incorporated macromolecules.

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