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Abstract #0992

High-Resolution 1 H-MRSI of the Brain using Short-TE SPICE

Chao Ma 1 , Fan Lam 1,2 , Qiang Ning 1,2 , Curtis L. Johnson 1 , and Zhi-Pei Liang 1,2

1 Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States, 2 Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Illinois, United States

SPICE (SPectroscopic Imaging by exploiting spatiospectral CorrElation) is emerging as a powerful tool for high-resolution spectroscopic imaging of the brain. As voxel size is getting smaller at higher resolution, further improvement of signal-to-noise ratio (SNR) becomes essential, especially with sparse sampling in (k,t)-space. This work presents a novel data acquisition and processing method to enable short-TE SPICE for high-resolution 1H-MRSI of the brain. In vivo experimental results show that the proposed method can achieve 2mm in-plane resolution in good SNR with a TE of 20ms in a 30min scan.

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