Abstract #0993
Application of a dipolar model to inhomogeneous magnetization transfer (ihMT)
Gopal Varma 1 , Olivier M Girard 2 , Valentin Prvost 2 , Aaron K Grant 1 , Guillaume Duhamel 2 , and David C Alsop 1
1
Radiology, Division of MR Research, Beth
Israel Deaconess Medical Center, Harvard Medical School,
Boston, Massachusetts, United States,
2
CRMBM
UMR 7339, CNRS and Aix-Marseille Universit, Marseille,
France
The inhomogeneous magnetization transfer technique (ihMT)
has gained attention for producing myelin selective
images, but a model for its mechanism has not been
established. This work develops a model based on
existing applications of the Redfield-Provotorov theory
to regular MT that predicted a dipolar order. The
results from model fitting to mouse and human data
provide measurable values for a relaxation time of the
dipolar order,
T
D
,
consistent with the observable ihMT signal. The
variation observed in
T
D
between
different regions of interest might provide further
insight into the selectivity and/or optimization of the
ihMT technique.
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