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Abstract #0993

Application of a dipolar model to inhomogeneous magnetization transfer (ihMT)

Gopal Varma 1 , Olivier M Girard 2 , Valentin Prvost 2 , Aaron K Grant 1 , Guillaume Duhamel 2 , and David C Alsop 1

1 Radiology, Division of MR Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States, 2 CRMBM UMR 7339, CNRS and Aix-Marseille Universit, Marseille, France

The inhomogeneous magnetization transfer technique (ihMT) has gained attention for producing myelin selective images, but a model for its mechanism has not been established. This work develops a model based on existing applications of the Redfield-Provotorov theory to regular MT that predicted a dipolar order. The results from model fitting to mouse and human data provide measurable values for a relaxation time of the dipolar order, T D , consistent with the observable ihMT signal. The variation observed in T D between different regions of interest might provide further insight into the selectivity and/or optimization of the ihMT technique.

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