Oxidative stress sensitive magnetization transfer MRI of prostate cancer
Rongwen Tain 1,2 , Michael Abern 3 , Karen Xie 1 , X. Joe Zhou 1,2 , and Kejia Cai 1,2
Radiology, College of Medicine, University
of Illinois at Chicago, Chicago, Illinois, United
for MR Research, College of Medicine, University of
Illinois at Chicago, Chicago, Illinois, United States,
College of Medicine, University of Illinois at Chicago,
Chicago, Illinois, United States
Reduction-oxidation (Redox) imbalance due to oxidative
stress may occur in pathologies including cancer.
Developing imaging biomarkers for oxidative stress is a
key research area. Recently, we presented the first
non-invasive MRI method for mapping the tissue redox
state based on the endogenous Chemical Exchange
Saturation Transfer (CEST) contrast. It is well known
that magnetization transfer (MT) can occur via chemical
exchange (CEST) and/or dipole-dipole interactions
(Nuclear Overhauser Enhancement or NOE). This study on
ex vivo egg white tissues and in vivo prostate cancers
demonstrated that MT in the broad definition is
sensitive to oxidative stress through animal models.
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