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Abstract #0999

A new MT signal at -1.6 ppm via NOE-mediated saturation transfer

Xiao-Yong Zhang 1 , Hua Li 1 , Junzhong Xu 1 , Jingping Xie 1 , John C. Gore 1 , and Zhongliang Zu 1

1 Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States

Magnetization transfer (MT) provides a unique mechanism for producing contrast and makes MRI sensitive to the presence of metabolites, mobile macromolecules, and semisolid macromolecules through their magnetic coupling effects on the water signal. Although the nuclear Overhauser enhancement (NOE)-mediated MT signal at -3.5 ppm has been recently studied, to date no in vivo MT effect at -1.6 ppm has been reported. We report a new MT signal MT at -1.6 ppm, which may reflect the NOE effect between choline headgroup of membrane phospholipids and water protons. The MT signal at -1.6 ppm could be used as a new biomarker in healthy rat brain.

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