Abstract #0998
Study of Bound Proton T2 and Magnetization Transfer using Pulsed MT
Xu Jiang 1,2 , Peter van Gelderen 1 , Xiaozhen Li 1 , Emily Leibovitch 3 , Pascal Sati 4 , Afonso C. Silva 5 , and Jeff H Duyn 1
1
AMRI, LFMI, NINDS, NIH, Bethesda, MD, United
States,
2
Department
of Physics, University of Maryland, College Park, MD,
United States,
3
Viral
Immunology Section, Neuroimmunology Branch, NINDS, NIH,
Bethesda, MD, United States,
4
Translational
Neuroradiology Unit, NINDS, NIH, Bethesda, MD, United
States,
5
CMU,
LFMI, NINDS, NIH, Bethesda, MD, United States
Accurate knowledge of the T2 of bound (non-water)
protons is very essential for optimization and
quantification of MT contrast. Using optimized, 2ms long
binomial MT pulses with varying amplitudes, and studying
delay-dependent saturation of mobile water protons, we
determined bound proton T2 to average 27μs, 17.5μs and
13.5μs in white matter, grey matter, and muscle tissue
in marmoset in vivo, while the exchange rates between
water and non-water protons were 13s-1, 30s-1, and 47s-1
respectively. The pulse-delay approach followed here
proved a sensitive way to study MT contrast and is
applicable to study of human brain at high field.
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