Abstract #1002

Amplifying ATP Magnetization Exchange Effects by Band Inversion Transfer: A 31P NMR Study in Human Skeletal Muscle at 7T

Jimin Ren ^1,2 , Baolian Yang ³ , A. Dean Sherry ^1,4 , and Craig R. Malloy ^1,5

¹ Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, United States, ² Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States, ³ Philips Healthcare, Cleveland, Ohio, United States, ⁴ Department of Chemistry, University of Texas at Dallas, Richardson, Texas, United States, ⁵ VA North Texas Health Care System, Dallas, Texas, United States

31P magnetization transfer studies in animals and humans suggest that transfer occurs not only between ATP and exchanging metabolites such as phosphocreatine and inorganic phosphate, but also among ATP spins. The latter effect, although small, is most consistent with 31P-31P NOE. Here, we explore a strategy to amplify this exchange effect within ATP by using a wideband inversion. A four-fold increase in lower case Greek beta

-ATP signal reduction was observed by simultaneously inverting Pi, PCr, lower case Greek alpha

- and lower case Greek gamma

-ATP using an adiabatic pulse, as compared to by conventional frequency-selective inversion of only lower case Greek gamma

-ATP. This observation is not consistent with known chemical exchange pathways.

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