Abstract #1002
Amplifying ATP Magnetization Exchange Effects by Band Inversion Transfer: A 31P NMR Study in Human Skeletal Muscle at 7T
Jimin Ren 1,2 , Baolian Yang 3 , A. Dean Sherry 1,4 , and Craig R. Malloy 1,5
1
Advanced Imaging Research Center, University
of Texas Southwestern Medical Center, Dallas, Texas,
United States,
2
Department
of Radiology, University of Texas Southwestern Medical
Center, Dallas, Texas, United States,
3
Philips
Healthcare, Cleveland, Ohio, United States,
4
Department
of Chemistry, University of Texas at Dallas, Richardson,
Texas, United States,
5
VA
North Texas Health Care System, Dallas, Texas, United
States
31P magnetization transfer studies in animals and humans
suggest that transfer occurs not only between ATP and
exchanging metabolites such as phosphocreatine and
inorganic phosphate, but also among ATP spins. The
latter effect, although small, is most consistent with
31P-31P NOE. Here, we explore a strategy to amplify this
exchange effect within ATP by using a wideband
inversion. A four-fold increase in
-ATP
signal reduction was observed by simultaneously
inverting Pi, PCr,
-
and
-ATP
using an adiabatic pulse, as compared to by conventional
frequency-selective inversion of only
-ATP.
This observation is not consistent with known chemical
exchange pathways.
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