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Abstract #1003

Multi-center Evaluation of Accelerated 3D Magnetic Resonance Perfusion Imaging for Assessing Myocardial Ischemic Burden to Detect Coronary Heart Disease

Robert Manka 1,2 , Lukas Wissmann 2 , Rolf Gebker 3 , Roy Jogiya 4 , Manish Motwani 5 , Michael Frick 6 , Sebastian Reinartz 6 , Bernhard Schnackenburg 3 , Markus Niemann 2 , Alexander Gotschy 1 , Christiane Kuhl 6 , Eike Nagel 4 , Eckart Fleck 3 , Thomas F Luescher 1 , Sven Plein 5 , and Sebastian Kozerke 2,4

1 University Hospital Zurich, Zurich, Switzerland, 2 University and ETH Zurich, Zurich, Switzerland, 3 German Heart Institute, Berlin, Germany, 4 King's College London, United Kingdom, 5 University of Leeds, United Kingdom, 6 University Hospital Aachen, Germany

In this multi-center study the diagnostic performance of accelerated 3D myocardial perfusion imaging to detect functionally relevant coronary heart disease (CAD) was assessed relative to the invasive fractional flow reserve (FFR) reference standard. The sensitivity and specificity of myocardial ischemic burden as a metric to assess severity of CAD were 84.7% and 92.3% relative to the FFR reference confirming excellent diagnostic yield of 3D perfusion imaging in a multi-center setting.

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