Abstract #1006
Towards a synergistic application of multimodal MR/PET myocardial perfusion imaging: Measuring capillary transit time heterogeneity with MRI and blood flow with simultaneous N-13 Ammonia PET
Karl Philipp Kunze 1 , Christoph Rischpler 1 , Shelley Zhang 2 , Carmel Hayes 3 , Markus Schwaiger 1 , and Stephan Nekolla 1
1
Klinikum rechts der Isar der Technischen
Universitt Mnchen, Mnchen, Bayern, Germany,
2
Brigham
and Women's Hospital, Boston, MA, United States,
3
Siemens
Medical Solutions, Erlangen, Bayern, Germany
This study aims to present a first synergistic approach
to simultaneous MR/PET myocardial perfusion imaging. On
the MR side, a new method to assess vascular dynamics by
quantifying capillary transit time heterogeneity in
different vasodilatation states is introduced. The
advantages of transit time related perfusion parameters
concerning quantification with MRI as compared to
volume-related parameters such as flow are exploited for
the first time with a specific physiological
interpretation (oxygen extraction efficacy). MRI results
are combined with an established method for flow
quantification on the PET side, with patient data
exemplifying the synergistic potential of the combined
approach.
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