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Abstract #1006

Towards a synergistic application of multimodal MR/PET myocardial perfusion imaging: Measuring capillary transit time heterogeneity with MRI and blood flow with simultaneous N-13 Ammonia PET

Karl Philipp Kunze 1 , Christoph Rischpler 1 , Shelley Zhang 2 , Carmel Hayes 3 , Markus Schwaiger 1 , and Stephan Nekolla 1

1 Klinikum rechts der Isar der Technischen Universitt Mnchen, Mnchen, Bayern, Germany, 2 Brigham and Women's Hospital, Boston, MA, United States, 3 Siemens Medical Solutions, Erlangen, Bayern, Germany

This study aims to present a first synergistic approach to simultaneous MR/PET myocardial perfusion imaging. On the MR side, a new method to assess vascular dynamics by quantifying capillary transit time heterogeneity in different vasodilatation states is introduced. The advantages of transit time related perfusion parameters concerning quantification with MRI as compared to volume-related parameters such as flow are exploited for the first time with a specific physiological interpretation (oxygen extraction efficacy). MRI results are combined with an established method for flow quantification on the PET side, with patient data exemplifying the synergistic potential of the combined approach.

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