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Abstract #1007

Quantitative Dynamic Contrast Enhanced MRI in Acute ST-Elevated Myocardial Infarction: Blood Flow, Microvascular Permeability and Interstitial Volume in Infarct and Peri-Infarct Edema

David A Broadbent 1,2 , Ananth Kidambi 2 , Sven Plein 2 , and David L Buckley 1,2

1 Division of Medical Physics, University of Leeds, Leeds, West Yorkshire, United Kingdom, 2 Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, West Yorkshire, United Kingdom

Dynamic Contrast Enhanced MRI has been used to quantify relative and absolute myocardial blood flow in health and disease. Measurement of additional parameters, including microvascular permeability and contrast agent distribution volumes, through application of a distributed parameter model, has also previously been reported. In this work these methods were applied in a cohort of patients with acute ST-Elevation Myocardial Infarction (STEMI) to allow assessment of these physiological parameters in infarcted and peri-infarct edematous myocardium.

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