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Abstract #1035

Non-contrast enhanced non-invasive detection and follow-up of lung tumors in mice

Andrea Bianchi 1 , Sandrine Dufort 2,3 , Pierre-Yves Fortin 1,4 , Franois Lux 5 , Gerard Raffard 1 , Nawal Tassali 1 , Olivier Tillement 5 , Jean-Luc Coll 2 , and Yannick Crmillieux 1

1 Centre de Rsonance Magntique des Systmes Biologiques, University of Bordeaux, Bordeaux, Bordeaux, France, 2 IAB-INSERM U823, University Joseph Fourier, Grenoble, France, 3 Nano-H, Saint Quentin Fallavier, France, 4 Institut de Bio-Imagerie (IBIO) CNRS/UMS 3428, University of Bordeaux, Bordeaux, France, 5 ILM UMR 5306, University Lyon 1, Lyon, France

Lung cancer is the leading cause of cancer deaths worldwide. MRI can play a major role being a noninvasive imaging technique, characterized by good soft tissue contrast, high spatial resolution, and absence of ionizing radiation. We propose here an in vivo MRI longitudinal study of lung adenocarcinoma detection in tumor-bearing immunodeficient mice without the use of contrast agents. Free-breathing Ultra-short Echo Time (UTE) MRI acquisitions were compared to standard gradient echo lung MR images using both respiratory-gated and free-breathing protocols. The results were validated against Bioluminescence Imaging (BLI) and histology.

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