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Abstract #1034

In-vivo Imaging of the Spectral Line Broadening of the Human Lung in a Single Breath-Hold

Flavio Carinci 1,2 , Cord Meyer 2 , Felix A. Breuer 1 , and Peter M. Jakob 1,2

1 Research Center Magnetic Resonance Bavaria (MRB), Wrzburg, Bayern, Germany, 2 Department of Experimental Physics 5, University of Wrzburg, Wrzburg, Bayern, Germany

Susceptibility differences at air/tissue interfaces in the lung result in a broad NMR spectral line. The line broadening provides a quantitative fingerprint for lung inflation and may be used to diagnose air trapping or ventilation defects. Quantification of the line broadening of the lung has been previously proposed, using an asymmetric spin-echo (ASE) sequence. In this work, a fast technique based on a HASTE sequence with ASE preparation is presented. Quantification of the line broadening of the human lung in-vivo is feasible in a single breath-hold and may be suitable for clinical studies on patients with lung diseases. The results obtained in the lung parenchyma (about 1.5ppm) are in very good agreement with the ones predicted by numerical simulations.

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