Abstract #1034
In-vivo Imaging of the Spectral Line Broadening of the Human Lung in a Single Breath-Hold
Flavio Carinci 1,2 , Cord Meyer 2 , Felix A. Breuer 1 , and Peter M. Jakob 1,2
1
Research Center Magnetic Resonance Bavaria (MRB),
Wrzburg, Bayern, Germany,
2
Department
of Experimental Physics 5, University of Wrzburg,
Wrzburg, Bayern, Germany
Susceptibility differences at air/tissue interfaces in
the lung result in a broad NMR spectral line. The line
broadening provides a quantitative fingerprint for lung
inflation and may be used to diagnose air trapping or
ventilation defects. Quantification of the line
broadening of the lung has been previously proposed,
using an asymmetric spin-echo (ASE) sequence. In this
work, a fast technique based on a HASTE sequence with
ASE preparation is presented. Quantification of the line
broadening of the human lung in-vivo is feasible in a
single breath-hold and may be suitable for clinical
studies on patients with lung diseases. The results
obtained in the lung parenchyma (about 1.5ppm) are in
very good agreement with the ones predicted by numerical
simulations.
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