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Abstract #1033

Fractional Ventilation Mapping using Inert Fluorinated Gas MRI in a Rat Model of Inflammation

Marcus J. Couch 1,2 , Matthew S. Fox 3,4 , Chris Viel 1,2 , Gowtham Gajawada 1,2 , Tao Li 2 , and Mitchell S. Albert 1,2

1 Lakehead University, Thunder Bay, Ontario, Canada, 2 Thunder Bay Regional Research Institute, Thunder Bay, Ontario, Canada, 3 Robarts Research Institute, London, Ontario, Canada, 4 Department of Medical Biophysics, Western University, London, Ontario, Canada

19 F MR imaging was performed in a rat model of pulmonary inflammation using SF 6 . Fractional ventilation maps and ventilation gradients were compared between controls and rats that were instilled with lipopolysaccharide. Ventilation gradients calculated from control rats showed the expected gravitational relationship, while ventilation gradients calculated from LPS-instilled rats showed the opposite trend. Inflammation may disrupt the expected gradient in lung compliance, and elevated alveolar wall thicknesses in LPS-instilled rats were confirmed by histology. Overall, 19 F MRI may be able to detect the presence of inflammation using a simple and inexpensive approach that can potentially be translated to humans.

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