Abstract #1038
Simultaneous imaging of lung structure and function using oxygen-enhanced MRI in a mouse model of emphysema
Magdalena Zurek 1 , Louise Sladen 2 , Edvin Johansson 1 , Sonya Jackson 3 , Gaell Mayer 3 , and Paul D Hockings 2
1
PHB, Imaging, AstraZeneca R&D, Mlndal,
Sweden,
2
Drug
Safety and Metabolism, AstraZeneca R&D, Mlndal, Sweden,
3
RIA,
Bioscience, AstraZeneca R&D, Mlndal, Sweden
An oxygen-enhanced MRI protocol that permits
quantification of spatially matched ventilation and
oxygen uptake was implemented and applied to assess the
relationships between lung parenchyma density, oxygen
delivery and uptake in a mouse model of elastase-induced
lung emphysema. All parameters could be derived based on
parameters obtained from an inversion-recovery
experiment. Although no differences in global
enhancement were detected between the groups,
pixel-level analysis revealed differences between
control and treated mice that depended on tissue density
(damage). Significantly, treated animals showed larger
variations in oxygen uptake suggesting the ability of
the lungs functional reserve to compensate for the
non-performing regions.
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