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Abstract #1038

Simultaneous imaging of lung structure and function using oxygen-enhanced MRI in a mouse model of emphysema

Magdalena Zurek 1 , Louise Sladen 2 , Edvin Johansson 1 , Sonya Jackson 3 , Gaell Mayer 3 , and Paul D Hockings 2

1 PHB, Imaging, AstraZeneca R&D, Mlndal, Sweden, 2 Drug Safety and Metabolism, AstraZeneca R&D, Mlndal, Sweden, 3 RIA, Bioscience, AstraZeneca R&D, Mlndal, Sweden

An oxygen-enhanced MRI protocol that permits quantification of spatially matched ventilation and oxygen uptake was implemented and applied to assess the relationships between lung parenchyma density, oxygen delivery and uptake in a mouse model of elastase-induced lung emphysema. All parameters could be derived based on parameters obtained from an inversion-recovery experiment. Although no differences in global enhancement were detected between the groups, pixel-level analysis revealed differences between control and treated mice that depended on tissue density (damage). Significantly, treated animals showed larger variations in oxygen uptake suggesting the ability of the lungs functional reserve to compensate for the non-performing regions.

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