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Abstract #1039

3 He MRI and CT Parametric Response Mapping of Small Airways Disease: The Battle-Ground for Ground Truth

Dante Capaldi 1,2 , Nanxi Zha 1 , Damien Pike 1,2 , Khadija Sheikh 1,2 , David G McCormack 3 , and Grace Parraga 1,2

1 Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada, 2 Department of Medical Biophysics, The University of Western Ontario, London, Ontario, Canada, 3 Division of Respirology, Department of Medicine, The University of Western Ontario, London, Ontario, Canada

We compared hyperpolarized MRI ventilation and CT-derived parametric-response-mapping (PRM) measurements surrogate measurements of small airways disease, in 40 COPD patients. In mild COPD, there were fewer, smaller ventilation defects, negligible category II (small airways disease) and no category III voxels (emphysema). Severe COPD was reflected by a greater number and volume of ventilation defects and a greater number of category III (emphysema) voxels. MRI VDP was significantly correlated with category II CT voxels in mild but not moderate-severe COPD supporting the use of CT-derived PRM measurements of gas trapping related to small airway remodeling in mild but not moderate-severe COPD.

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