Abstract #1039
3 He MRI and CT Parametric Response Mapping of Small Airways Disease: The Battle-Ground for Ground Truth
Dante Capaldi 1,2 , Nanxi Zha 1 , Damien Pike 1,2 , Khadija Sheikh 1,2 , David G McCormack 3 , and Grace Parraga 1,2
1
Imaging Research Laboratories, Robarts
Research Institute, London, Ontario, Canada,
2
Department
of Medical Biophysics, The University of Western
Ontario, London, Ontario, Canada,
3
Division
of Respirology, Department of Medicine, The University
of Western Ontario, London, Ontario, Canada
We compared hyperpolarized MRI ventilation and
CT-derived parametric-response-mapping (PRM)
measurements surrogate measurements of small airways
disease, in 40 COPD patients. In mild COPD, there were
fewer, smaller ventilation defects, negligible category
II (small airways disease) and no category III voxels
(emphysema). Severe COPD was reflected by a greater
number and volume of ventilation defects and a greater
number of category III (emphysema) voxels. MRI VDP was
significantly correlated with category II CT voxels in
mild but not moderate-severe COPD supporting the use of
CT-derived PRM measurements of gas trapping related to
small airway remodeling in mild but not moderate-severe
COPD.
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